Adolescent neurostimulation of dopamine circuit reverses genetic deficits in frontal cortex function.

ABSTRACT: Dopamine system dysfunction is commonly implicated in adolescent-onset neuropsychiatric disorders. Although psychosis symptoms can be alleviated by antipsychotics, cognitive symptoms remain unresponsive to such pharmacological treatments and novel research paradigms investigating the circuit substrates underlying cognitive deficits are critically needed. The frontal cortex and its dopaminergic input from the midbrain are implicated in cognitive functions and undergo maturational changes during adolescence. Here, we used mice carrying mutations in the Arc or DISC1 genes to model mesofrontal dopamine circuit deficiencies and test circuit-based neurostimulation strategies to restore cognitive functions. We found that in a memory-guided spatial navigation task, frontal cortical n

SUBMITTER: Mastwal S 

PROVIDER: S-EPMC9915739 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature