Peripheral immune-derived matrix metalloproteinase promotes stress susceptibility.

ABSTRACT: Psychosocial stress has profound effects on the body, including the peripheral immune system and the brain^1,2. Although a large number of pre-clinical and clinical studies have linked peripheral immune system alterations to stress-related disorders such as major depressive disorder (MDD)^3,4,5, the underlying mechanisms are not well understood. Here we show that a peripheral myeloid cell-specific proteinase, matrix metalloproteinase 8 (MMP8), is elevated in serum of subjects with MDD as well as in stress-susceptible (SUS) mice following chronic social defeat stress (CSDS). In mice, we show that this increase leads to alterations in extracellular space and neurophysiological changes in the nucleus accumbens (NAc), thereby altering social behaviour. Using a combination o

SUBMITTER: Cathomas F 

PROVIDER: S-EPMC9915787 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature