Pre-existing autoimmunity is associated with increased severity of COVID-19: A retrospective cohort study using data from the National COVID Cohort Collaborative (N3C).

ABSTRACT:

Importance

Identifying individuals with a higher risk of developing severe COVID-19 outcomes will inform targeted or more intensive clinical monitoring and management.

Objective

To examine, using data from the National COVID Cohort Collaborative (N3C), whether patients with pre-existing autoimmune disease (AID) diagnosis and/or immunosuppressant (IS) exposure are at a higher risk of developing severe COVID-19 outcomes.

Design setting and participants

A retrospective cohort of 2,453,799 individuals diagnosed with COVID-19 between January 1 ^st , 2020, and June 30 ^th , 2022, was created from the N3C data enclave, which comprises data of 15,231,849 patients from 75 USA data partners. Patients were stratified as those with/without a pre-existing diagn

SUBMITTER: Yadaw AS 

PROVIDER: S-EPMC9915827 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature