Altered transcriptomes, cell type proportions, and dendritic spine morphology in hippocampus of suicide deaths.

ABSTRACT: Suicide is a condition resulting from complex environmental and genetic risks that affect millions of people globally. Both structural and functional studies identified the hippocampus as one of the vulnerable brain regions contributing to suicide risk. Here, we have identified the hippocampal transcriptomes, gene ontology, cell type proportions, dendritic spine morphology, and transcriptomic signature in iPSC-derived neuronal precursor cells (NPCs) and neurons in postmortem brain tissue from suicide deaths. The hippocampal tissue transcriptomic data revealed that NPAS4 gene expression was downregulated while ALDH1A2, NAAA, and MLXIPL gene expressions were upregulated in tissue from suicide deaths. The gene ontology identified 29 significant pathways including NPAS4

SUBMITTER: Das SC 

PROVIDER: S-EPMC9915834 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature