Pro- vs. Anti-Inflammatory Features of Monocyte Subsets in Glioma Patients.

ABSTRACT: Monocytes constitute a heterogenous group of antigen-presenting cells that can be subdivided based on CD14, CD16 and SLAN expression. This division reflects the functional diversity of cells that may play different roles in a variety of pathologies including gliomas. In the current study, the three monocyte subpopulations: classical (CD14⁺ CD16⁺ SLAN^-), intermediate (CD14^dim CD16⁺ SLAN^-) and non-classical (CD14^low/- CD16⁺ SLAN⁺) in glioma patients' peripheral blood were analysed with flow cytometry. The immune checkpoint molecule (PD-1, PD-L1, SIRPalpha, TIM-3) expression along with pro- and anti-inflammatory cytokines (TNF, IL-12, TGF-beta, IL-10) were assessed. The significant overproductio

SUBMITTER: Lehman N 

PROVIDER: S-EPMC9915868 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature