Associations between early-life exposure to PM_2.5 and reductions in childhood lung function in two North American longitudinal pregnancy cohort studies.

ABSTRACT: Data integration of epidemiologic studies across different geographic regions can provide enhanced exposure contrast and statistical power to examine adverse respiratory effects of early-life exposure to particulate matter <2.5 microns in diameter (PM_2.5). Methodological tools improve our ability to combine data while more fully accounting for study heterogeneity.

Methods

Analyses included children enrolled in two longitudinal birth cohorts in Boston, Massachusetts, and Mexico City. Propensity score matching using the 1:3 nearest neighbor with caliper method was used. Residential PM_2.5 exposure was estimated from 2 months before birth to age 6 years using a validated satellite-based spatiotemporal model. Lung function was tested at ages 6-11 years and age, heig

SUBMITTER: Rosa MJ 

PROVIDER: S-EPMC9915957 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature