MiRNA Differences Related to Treatment-Resistant Schizophrenia.

ABSTRACT: Schizophrenia (SZ) is a serious mental disorder that is typically treated with antipsychotic medication. Treatment-resistant schizophrenia (TRS) is the condition where symptoms remain after pharmacological intervention, resulting in long-lasting functional and social impairments. As the identification and treatment of a TRS patient requires previous failed treatments, early mechanisms of detection are needed in order to quicken the access to effective therapy, as well as improve treatment adherence. In this study, we aim to find a microRNA (miRNA) signature for TRS, as well as to shed some light on the molecular pathways potentially involved in this severe condition. To do this, we compared the blood miRNAs of schizophrenia patients that respond to medication and TRS patients, thus obtaini

SUBMITTER: Perez-Rodriguez D 

PROVIDER: S-EPMC9916039 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature