Role of NF-κB Signaling in the Interplay between Multiple Myeloma and Mesenchymal Stromal Cells.

ABSTRACT: Nuclear factor-κB (NF-κB) transcription factors play a key role in the pathogenesis of multiple myeloma (MM). The survival, proliferation and chemoresistance of malignant plasma cells largely rely on the activation of canonical and noncanonical NF-κB pathways. They are triggered by cancer-associated mutations or by the autocrine and paracrine production of cytokines and growth factors as well as direct interaction with cellular and noncellular components of bone marrow microenvironment (BM). In this context, NF-κB also significantly affects the activity of noncancerous cells, including mesenchymal stromal cells (MSCs), which have a critical role in disease progression. Indeed, NF-κB transcription factors are involved in inflammatory signaling that alters the functional properties of these

SUBMITTER: Cippitelli M 

PROVIDER: S-EPMC9916119 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature