Multi-omics characterization of RNA binding proteins reveals disease comorbidities and potential drugs in COVID-19.

ABSTRACT: The COVID-19 has led to a devastating global health crisis, which emphasizes the urgent need to deepen our understanding of the molecular mechanism and identifying potential antiviral drugs. Here, we comprehensively analyzed the transcriptomic and proteomic profiles of 178 COVID-19 patients, ranging from asymptomatic to critically ill. Our analyses found that the RNA binding proteins (RBPs) were likely to be perturbed in infection. Interactome analysis revealed that RBPs interact with virus proteins and the viral interacting RBPs were likely to locate in central regions of human protein-protein interaction network. Functional enrichment analysis revealed that the viral interacting RBPs were likely to be enriched in RNA transport, apoptosis and viral genome replication-related pathways. Bas

SUBMITTER: Pan J 

PROVIDER: S-EPMC9916187 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature