Antifibrotic Soluble Thy-1 Correlates with Renal Dysfunction in Chronic Kidney Disease.

ABSTRACT: Kidney fibrosis is a major culprit in the development and progression of chronic kidney disease (CKD), ultimately leading to the irreversible loss of organ function. Thymocyte differentiation antigen-1 (Thy-1) controls many core functions of fibroblasts relevant to fibrogenesis but is also found in a soluble form (sThy-1) in serum and urine. We investigated the association of sThy-1 with clinical parameters in patients with CKD receiving hemodialysis treatment compared to individuals with a preserved renal function. Furthermore, Thy-1 tissue expression was detected in a mouse model of diabetic CKD (eNOS^-/-; db/db) and non-diabetic control mice (eNOS^-/-). Serum and urinary sThy-1 concentrations significantly increased with deteriorating renal function, independent of t

SUBMITTER: Saalbach A 

PROVIDER: S-EPMC9916214 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature