Genetic Background and Molecular Mechanisms of Juvenile Idiopathic Arthritis.

ABSTRACT: Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in the paediatric population. JIA comprises a heterogeneous group of disorders with different onset patterns and clinical presentations with the only element in common being chronic joint inflammation. This review sought to evaluate the most relevant and up-to-date evidence on current knowledge regarding the pathogenesis of JIA subtypes to provide a better understanding of these disorders. Despite significant improvements over the past decade, the aetiology and molecular mechanisms of JIA remain unclear. It has been suggested that the immunopathogenesis is characterised by complex interactions between genetic background and environmental factors that may differ between JIA subtypes. Human leukocyte antigen (HL

SUBMITTER: La Bella S 

PROVIDER: S-EPMC9916312 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature