Air Pollution and Atopic Dermatitis, from Molecular Mechanisms to Population-Level Evidence: A Review.

ABSTRACT: Atopic dermatitis (AD) has increased in prevalence to become the most common inflammatory skin condition globally, and geographic variation and migration studies suggest an important role for environmental triggers. Air pollution, especially due to industrialization and wildfires, may contribute to the development and exacerbation of AD. We provide a comprehensive, multidisciplinary review of existing molecular and epidemiologic studies on the associations of air pollutants and AD symptoms, prevalence, incidence, severity, and clinic visits. Cell and animal studies demonstrated that air pollutants contribute to AD symptoms and disease by activating the aryl hydrocarbon receptor pathway, promoting oxidative stress, initiating a proinflammatory response, and disrupting the skin barrier funct

SUBMITTER: Fadadu RP 

PROVIDER: S-EPMC9916398 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature