Exploring the Biological Properties of Zn(II) Bisthiosemicarbazone Helicates.

ABSTRACT: The design of artificial helicoidal molecules derived from metal ions with biological properties is one of the objectives within metallosupramolecular chemistry. Herein, we report three zinc helicates derived from a family of bisthiosemicarbazone ligands with different terminal groups, Zn₂(L^Me)₂∙2H₂O 1, Zn₂(L^Ph)₂∙2H₂O 2 and Zn₂(L^PhNO2)₂3, obtained by an electrochemical methodology. These helicates have been fully characterized by different techniques, including X-ray diffraction. Biological studies of the zinc(II) helicates such as toxicity assays with erythrocytes and interaction studies with proteins and oligonucleotides were performed, demo

SUBMITTER: Fernandez-Farina S 

PROVIDER: S-EPMC9916454 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature