Differential Roles of Cystathionine Gamma-Lyase and Mercaptopyruvate Sulfurtransferase in Hapten-Induced Colitis and Contact Dermatitis in Mice.

ABSTRACT: Hydrogen sulfide (H₂S) has been shown to act as both anti-inflammatory and pro-inflammatory mediators. Application of H₂S donors generally protects against inflammation; however, experimental results using mice lacking endogenous H₂S-producing enzymes, such as cystathionine γ-lyase (CTH) and mercaptopyruvate sulfurtransferase (MPST), are often contradictory. We herein examined two types of model hapten-induced inflammation models, colitis (an inflammatory bowel disease model of mucosal immunity) and contact dermatitis (a type IV allergic model of systemic immunity), in CTH-deficient (Cth^-/-) and MPST-deficient (Mpst^-/-) mice. Both mice exhibited no significant alteration from wild-type mice in trinitrobenzene sulfonic aci

SUBMITTER: Akahoshi N 

PROVIDER: S-EPMC9916491 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature