In Vitro and In Vivo Effects of IGF-1 Delivery Strategies on Tendon Healing: A Review.

ABSTRACT: Tendon injuries suffer from a slow healing, often ending up in fibrovascular scar formation, leading to inferior mechanical properties and even re-rupture upon resumption of daily work or sports. Strategies including the application of growth factors have been under view for decades. Insulin-like growth factor-1 (IGF-1) is one of the used growth factors and has been applied to tenocyte in vitro cultures as well as in animal preclinical models and to human patients due to its anabolic and matrix stimulating effects. In this narrative review, we cover the current literature on IGF-1, its mechanism of action, in vitro cell cultures (tenocytes and mesenchymal stem cells), as well as in vivo experiments. We conclude from this overview that IGF-1 is a potent stimulus for improving tendon healing

SUBMITTER: Miescher I 

PROVIDER: S-EPMC9916536 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature