N-Doped Carbon/CeO₂ Composite as a Biomimetic Catalyst for Antibacterial Application.

ABSTRACT: Exploring new and high efficiency mimic enzymes is a vital and novel strategy for antibacterial application. Haloperoxidase-like enzymes have attracted wide attention thanks to their amazing catalytic property for hypohalous acid generation from hydrogen peroxide and halides. However, few materials have displayed halogenating catalytic performance until now. Herein, we synthesized N-doped C/CeO₂ (N-C/CeO₂) composite materials by a combination of the liquid and solid-state method. N-C/CeO₂ can possess haloperoxidase-like catalytic activity by catalyzing the bromination of organic signaling compounds (phenol red) with H₂O₂ at a wide range of temperatures (20 °C to 55 °C), with a solution color changing from yellow to blue. Meanwhile, it exhibits high catalytic stability/recyclability in the catalytic reaction. The synthesized N-C/CeO₂ composite can effectively catalyze the oxidation of Br^- with H₂O₂ to produce HBrO without the presence of phenol red. The produced HBrO can resist typical marine bacteria like Pseudomonas aeruginosa. This study provides an efficient biomimetic haloperoxidase and a novel sustainable method for antibacterial application.

SUBMITTER: Wang N 

PROVIDER: S-EPMC9916758 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature