A Combination of Caffeine Supplementation and Enriched Environment in an Alzheimer's Disease Mouse Model.

ABSTRACT: A variety of factors has been associated with healthy brain aging, and epidemiological studies suggest that physical activity and nutritional supplements such as caffeine may reduce the risk of developing dementia and, in particular, Alzheimer's disease (AD) in later life. Caffeine is known to act as a cognitive enhancer but has been also shown to positively affect exercise performance in endurance activities. We have previously observed that chronic oral caffeine supplementation and a treatment paradigm encompassing physical and cognitive stimulation by enriched environment (EE) housing can improve learning and memory performance and ameliorate hippocampal neuron loss in the Tg4-42 mouse model of AD. Here, we investigated whether these effects were synergistic. To that end, previous findi

SUBMITTER: Stazi M 

PROVIDER: S-EPMC9916825 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature