SFgl2-Treg Positive Feedback Pathway Protects against Atherosclerosis.

ABSTRACT: Soluble fibrinogen-like protein 2 (sFgl2), a novel effector of regulatory T cells (Tregs), has been demonstrated to have potent immunosuppressive functions. Multiple studies indicate that Tregs could exert important atheroprotective effects, but their numbers gradually decrease during atherogenesis. The receptor of sFgl2 can be expressed on Treg precursor cells, while the role of sFgl2 on Treg differentiation and atherosclerosis progression remains unclear. Firstly, we detected that the sFgl2 was decreased in humans and mice with atherosclerotic diseases and was especially lower in their vulnerable plaques. Then, we used both Adeno-associated virus-sFgl2 (AAV-sFgl2)-injected ApoE^-/- mice, which is systemic overexpression of sFgl2, and sFgl2^TgApoE^-/- bone ma

SUBMITTER: An T 

PROVIDER: S-EPMC9916961 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature