An ELOVL2-Based Epigenetic Clock for Forensic Age Prediction: A Systematic Review.

ABSTRACT: The prediction of chronological age from methylation-based biomarkers represents one of the most promising applications in the field of forensic sciences. Age-prediction models developed so far are not easily applicable for forensic caseworkers. Among the several attempts to pursue this objective, the formulation of single-locus models might represent a good strategy. The present work aimed to develop an accurate single-locus model for age prediction exploiting ELOVL2, a gene for which epigenetic alterations are most highly correlated with age. We carried out a systematic review of different published pyrosequencing datasets in which methylation of the ELOVL2 promoter was analysed to formulate age prediction models. Nine of these, with available datasets involving 2298 partic

SUBMITTER: Paparazzo E 

PROVIDER: S-EPMC9916975 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature