Ontology highlight
ABSTRACT:
SUBMITTER: Yang K
PROVIDER: S-EPMC9916986 | biostudies-literature | 2023 Feb
REPOSITORIES: biostudies-literature
Yang Kaiyong K Li Zijian Z Chen Yan Y Yin Fangzhou F Ji Xiaojun X Zhou Jiaqian J Li Xin X Zeng Tao T Fei Chenghao C Ren Chenchen C Wang Yulin Y Fang Lei L Chen Lili L Zhang Pei P Mu Liyan L Qian Yuxuan Y Chen Yan Y Yin Wu W
Science advances 20230210 6
Dysregulated endocrine hormones (EHs) contribute to tumorigenesis, but how EHs affect the tumor immune microenvironment (TIM) and the immunotherapy of non-small cell lung cancer (NSCLC) is still unclear. Here, endogenous ouabain (EO), an adrenergic hormone, is elevated in patients with NSCLC and closely related to tumor pathological stage, metastasis, and survival. EO promotes the suppression of TIM in vivo by modulating the expression of immune checkpoint proteins, in which programmed cell deat ...[more]