Convergent abnormalities in striatal gene networks in human cocaine use disorder and mouse cocaine administration models.

ABSTRACT: Cocaine use disorder (CUD) is an intractable syndrome, and rising overdose death rates represent a substantial public health crisis that exacts tremendous personal and financial costs on patients and society. Sharp increases in cocaine use drive the urgent need for better mechanistic insight into this chronic relapsing brain disorder that currently lacks effective treatment options. To investigate the transcriptomic changes involved, we conducted RNA sequencing on two striatal brain regions that are heavily implicated in CUD, the nucleus accumbens and caudate nucleus, from men suffering from CUD and matched controls. Weighted gene coexpression analyses identified CUD-specific gene networks enriched in ionotropic receptors and linked to lowered neuroinflammation, contrasting the proinflamma

SUBMITTER: Mews P 

PROVIDER: S-EPMC9916993 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature