Ontology highlight
ABSTRACT:
SUBMITTER: Altendorf T
PROVIDER: S-EPMC9917023 | biostudies-literature | 2023 Jan
REPOSITORIES: biostudies-literature
Altendorf Tim T Gering Ian I Santiago-Schübel Beatrix B Aghabashlou Saisan Selma S Tamgüney Gültekin G Tusche Markus M Honold Dominik D Schemmert Sarah S Hoyer Wolfgang W Mohrlüder Jeannine J Willbold Dieter D
International journal of molecular sciences 20230121 3
Alzheimer's disease and other tauopathies are the world's leading causes of dementia and memory loss. These diseases are thought to be caused by the misfolding and aggregation of the intracellular tau protein, ultimately leading to neurodegeneration. The tau protein is involved in a multitude of different neurodegenerative diseases. During the onset of tauopathies, tau undergoes structural changes and posttranslational modifications and aggregates into amyloid fibrils that are able to spread wit ...[more]