Enhanced Antibacterial Activity of Substituted Derivatives of NCR169C Peptide.

ABSTRACT: Medicago truncatula in symbiosis with its rhizobial bacterium partner produces more than 700 nodule-specific cysteine-rich (NCR) peptides with diverse physicochemical properties. Most of the cationic NCR peptides have antimicrobial activity and the potential to tackle antimicrobial resistance with their novel modes of action. This work focuses on the antibacterial activity of the NCR169 peptide derivatives as we previously demonstrated that the C-terminal sequence of NCR169 (NCR169C_17-38) has antifungal activity, affecting the viability, morphology, and biofilm formation of various Candida species. Here, we show that NCR169C_17-38 and its various substituted derivatives are also able to kill ESKAPE pathogens such as Enterococcus faecalis, Staphy

SUBMITTER: Howan DHO 

PROVIDER: S-EPMC9917201 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature