Zinc Inhibits the GABA_AR/ATPase during Postnatal Rat Development: The Role of Cysteine Residue.

ABSTRACT: Zinc ions (Zn²⁺) are concentrated in various brain regions and can act as a neuromodulator, targeting a wide spectrum of postsynaptic receptors and enzymes. Zn²⁺ inhibits the GABA_ARs, and its potency is profoundly affected by the subunit composition and neuronal developmental stage. Although the extracellular amino acid residues of the receptor's hetero-oligomeric structure are preferred for Zn²⁺ binding, there are intracellular sites that, in principle, could coordinate its potency. However, their role in modulating the receptor function during postembryonic development remains unclear. The GABA_AR possesses an intracellular ATPase that enables the energy-dependent anion transport via a pore. Here, we propose a mechanistic and molecula

SUBMITTER: Menzikov SA 

PROVIDER: S-EPMC9917249 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature