Influence of Butyrate on Impaired Gene Expression in Colon from Patients with High Blood Pressure.

ABSTRACT: Hypertension (HTN) is associated with gut dysbiosis and the depletion of butyrate-producing bacteria in animal models and people. Furthermore, fecal material transfer from donor hypertensive patients increases blood pressure in normotensive recipient animals and ameliorates HTN-associated pathophysiology. These observations have implications in the impaired interactions between the gut and gut microbiota in HTN. Although this concept is supported in animal models, little is known about human HTN. Therefore, our objective for this study was to compare gene expression with transcriptomics and its potential to influence microbiota in subjects with normal and high blood pressure (HBP). Colon samples from reference subjects with normal blood pressure (REF) and HBP were used for RNA-seq to analy

SUBMITTER: Li J 

PROVIDER: S-EPMC9917256 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature