The Effect of Renal Denervation on T Cells in Patients with Resistant Hypertension.

ABSTRACT: (1) Background: Sympathetic overactivity is a major contributor to resistant hypertension (RH). According to animal studies, sympathetic overactivity increases immune responses, thereby aggravating hypertension and cardiovascular outcomes. Renal denervation (RDN) reduces sympathetic nerve activity in RH. Here, we investigate the effect of RDN on T-cell signatures in RH. (2) Methods: Systemic inflammation and T-cell subsets were analyzed in 17 healthy individuals and 30 patients with RH at baseline and 6 months after RDN. (3) Results: The patients with RH demonstrated higher levels of pro-inflammatory cytokines and higher frequencies of CD4+ effector memory (T_EM), CD4+ effector memory residential (T_EMRA) and CD8+ central memory (T_CM) cells than the controls.

SUBMITTER: Kantauskaite M 

PROVIDER: S-EPMC9917284 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature