Complexes of Cationic Pyridylphenylene Dendrimers with Anionic Liposomes: The Role of Dendrimer Composition in Membrane Structural Changes.

ABSTRACT: In the last decades, dendrimers have received attention in biomedicine that requires detailed study on the mechanism of their interaction with cell membranes. In this article, we report on the role of dendrimer structure in their interaction with liposomes. Here, the interactions between cationic pyridylphenylene dendrimers of the first, second, and third generations with mixed or completely charged pyridyl periphery (D₁⁶⁺, D₂¹⁵⁺, D₂²⁹⁺, and D₃⁵⁰⁺) with cholesterol-containing (CL/Chol/DOPC) anionic liposomes were investigated by microelectrophoresis, dynamic light scattering, fluorescence spectroscopy, and conductometry. It was found that the architecture of the dendrimer, namely the generation, the amo

SUBMITTER: Efimova AA 

PROVIDER: S-EPMC9917332 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature