Baseline Gait and Motor Function Predict Long-Term Severity of Neurological Outcomes of Viral Infection

ABSTRACT: Neurological dysfunction following viral infection varies among individuals, largely due to differences in their genetic backgrounds. Gait patterns, which can be evaluated using measures of coordination, balance, posture, muscle function, step-to-step variability, and other factors, are also influenced by genetic background. Accordingly, to some extent gait can be characteristic of an individual, even prior to changes in neurological function. Because neuromuscular aspects of gait are under a certain degree of genetic control, the hypothesis tested was that gait parameters could be predictive of neuromuscular dysfunction following viral infection. The Collaborative Cross (CC) mouse resource was utilized to model genetically diverse populations and the DigiGait treadmill system used to prov

SUBMITTER: Karmakar M 

PROVIDER: S-EPMC9917409 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature