A neuroepithelial wave of BMP signalling drives anteroposterior specification of the tuberal hypothalamus.

ABSTRACT: The tuberal hypothalamus controls life-supporting homeostatic processes, but despite its fundamental role, the cells and signalling pathways that specify this unique region of the central nervous system in embryogenesis are poorly characterised. Here, we combine experimental and bioinformatic approaches in the embryonic chick to show that the tuberal hypothalamus is progressively generated from hypothalamic floor plate-like cells. Fate-mapping studies show that a stream of tuberal progenitors develops in the anterior-ventral neural tube as a wave of neuroepithelial-derived BMP signalling sweeps from anterior to posterior through the hypothalamic floor plate. As later-specified posterior tuberal progenitors are generated, early specified anterior tuberal progenitors become progressively mor

SUBMITTER: Chinnaiya K 

PROVIDER: S-EPMC9917434 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature