Regulatory dissection of the severe COVID-19 risk locus introgressed by Neanderthals.

ABSTRACT: Individuals infected with the SARS-CoV-2 virus present with a wide variety of symptoms ranging from asymptomatic to severe and even lethal outcomes. Past research has revealed a genetic haplotype on chromosome 3 that entered the human population via introgression from Neanderthals as the strongest genetic risk factor for the severe response to COVID-19. However, the specific variants along this introgressed haplotype that contribute to this risk and the biological mechanisms that are involved remain unclear. Here, we assess the variants present on the risk haplotype for their likelihood of driving the genetic predisposition to severe COVID-19 outcomes. We do this by first exploring their impact on the regulation of genes involved in COVID-19 infection using a variety of population g

SUBMITTER: Jagoda E 

PROVIDER: S-EPMC9917435 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature