Talimogene Laherparepvec (T-VEC): A Review of the Recent Advances in Cancer Therapy.

ABSTRACT: The landscape of melanoma treatment has undergone a dramatic revolution in the past decade. The use of oncolytic viruses (OVs) represents a novel therapeutic approach that can selectively infect and lyse tumor cells and induce local and systemic antitumor immune responses. As the first OV approved by the Food and Drug Administration (FDA) for melanoma treatment, talimogene laherparepvec (T-VEC), a genetically modified herpes simplex virus (HSV), has shown promising therapeutic effects in the treatment of advanced melanoma, both as a monotherapy or in combination with other immunotherapies, such as the immune checkpoint inhibitors (ICIs). With proven efficacy, T-VEC has been evaluated against a variety of other cancer types in a clinical trial setting. In this article, we will provide a rev

SUBMITTER: Zhang T 

PROVIDER: S-EPMC9917711 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature