Barium sulfate and pigment admixture for photoacoustic and x-ray contrast imaging of the gut.

ABSTRACT:

Significance

X-ray imaging is frequently used for gastrointestinal imaging. Photoacoustic imaging (PAI) of the gastrointestinal tract is an emerging approach that has been demonstrated for preclinical imaging of small animals. A contrast agent active in both modalities could be useful for imaging applications.

Aim

We aimed to develop a dual-modality contrast agent comprising an admixture of barium sulfate with pigments that absorb light in the second near-infrared region (NIR-II), for preclinical imaging with both x-ray and PAI modalities.

Approach

Eleven different NIR-II dyes were evaluated after admixture with a 40% w/v barium sulfate mixture. The resulting NIR-II absorption in the soluble fraction and in the total mixture was characterized. Proof-of-principle imagi

SUBMITTER: Kilian HI 

PROVIDER: S-EPMC9917716 | biostudies-literature | 2023 Aug

REPOSITORIES: biostudies-literature