Asparagine and Glutamine Deprivation Alters Ionizing Radiation Response, Migration and Adhesion of a p53^null Colorectal Cancer Cell Line.

ABSTRACT: Colorectal cancer (CRC) is the most prominent form of colon cancer for both incidence (38.7 per 100,000 people) and mortality (13.9 per 100,000 people). CRC's poor response to standard therapies is linked to its high heterogeneity and complex genetic background. Dysregulation or depletion of the tumor suppressor p53 is involved in CRC transformation and its capability to escape therapy, with p53^null cancer subtypes known, in fact, to have a poor prognosis. In such a context, new therapeutic approaches aimed at reducing CRC proliferation must be investigated. In clinical practice, CRC chemotherapy is often combined with radiation therapy with the aim of blocking the expansion of the tumor mass or removing residual cancer cells, though contemporary targeting of amino acid metaboli

SUBMITTER: Guardamagna I 

PROVIDER: S-EPMC9917910 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature