Mechanisms of Prostate Cancer Cells Survival and Their Therapeutic Targeting.

ABSTRACT: Prostate cancer (PCa) is today the second most common cancer in the world, with almost 400,000 deaths annually. Multiple factors are involved in the etiology of PCa, such as older age, genetic mutations, ethnicity, diet, or inflammation. Modern treatment of PCa involves radical surgical treatment or radiation therapy in the stages when the tumor is limited to the prostate. When metastases develop, the standard procedure is androgen deprivation therapy, which aims to reduce the level of circulating testosterone, which is achieved by surgical or medical castration. However, when the level of testosterone decreases to the castration level, the tumor cells adapt to the new conditions through different mechanisms, which enable their unhindered growth and survival, despite the therapy. New knowl

SUBMITTER: Pejcic T 

PROVIDER: S-EPMC9917912 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature