Identification of S100A9 as a Potential Inflammation-Related Biomarker for Radiation-Induced Lung Injury.

ABSTRACT: Radiation-induced lung injury (RILI), a potentially fatal and dose-limiting complication of radiotherapy for thoracic tumors, is divided into early reversible pneumonitis and irreversible advanced-stage fibrosis. Early detection and intervention contribute to improving clinical outcomes of patients. However, there is still a lack of reliable biomarkers for early prediction and clinical diagnosis of RILI. Given the central role of inflammation in the initiation and progression of RILI, we explored specific inflammation-related biomarkers during the development of RILI in this study. Two expression profiles from the Gene Expression Omnibus (GEO) database were downloaded, in which 75 differentially expressed genes (DEGs) were screened out. Combining Gene Oncology (GO), Kyoto Encyclopedia of G

SUBMITTER: Liu Y 

PROVIDER: S-EPMC9917937 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature