Longevity, Centenarians and Modified Cellular Proteodynamics.

ABSTRACT: We have shown before that at least one intracellular proteolytic system seems to be at least as abundant in the peripheral blood lymphocytes of centenarians as in the same cells of young individuals (with the cells of the elderly population showing a significant dip compared to both young and centenarian cohorts). Despite scarce published data, in this review, we tried to answer the question how do different types of cells of longevous people-nonagenarians to (semi)supercentenarians-maintain the quality and quantity of their structural and functional proteins? Specifically, we asked if more robust proteodynamics participate in longevity. We hypothesized that at least some factors controlling the maintenance of cellular proteomes in centenarians will remain at the "young" level (just perfor

SUBMITTER: Frankowska N 

PROVIDER: S-EPMC9918038 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature