Systemic Immune Inflammation Index (SII), System Inflammation Response Index (SIRI) and Risk of All-Cause Mortality and Cardiovascular Mortality: A 20-Year Follow-Up Cohort Study of 42,875 US Adults.

ABSTRACT:

Background and aim

Chronic low-grade inflammation is associated with various health outcomes, including cardiovascular diseases (CVDs) and cancers. Systemic immune inflammation index (SII) and system inflammation response index (SIRI) have lately been explored as novel prognostic markers for all-cause mortality and cardiovascular mortality. However, studies on prediction value in nationwide representative population are scarce, which limit their generalization. To bridge the knowledge gap, this study aims to prospectively assess the association of SII, SIRI with all-cause mortality and cardiovascular mortality in the National Health and Nutrition Examination Survey (NHANES).

Methods

From 1999 to 2018, 42,875 adults who were free of pregnancy, CVDs (stroke, acute coronary syn

SUBMITTER: Xia Y 

PROVIDER: S-EPMC9918056 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature