Assessing overdiagnosis of fecal immunological test screening for colorectal cancer with a digital twin approach.

ABSTRACT: Evaluating the magnitude of overdiagnosis associated with stool-based service screening for colorectal cancer (CRC) beyond a randomized controlled trial is often intractable and understudied. We aim to estimate the proportion of overdiagnosis in population-based service screening programs for CRC with the fecal immunochemical test (FIT). The natural process of overdiagnosis-embedded disease was first built up to learn transition parameters that quantify the pathway of non-progressive and progressive screen-detected cases calibrated with sensitivity, while also taking competing mortality into account. The Markov algorithms were then developed for estimating these transition parameters based on Taiwan FIT service CRC screening data on 5,417,699 residents aged 50-69 years from 2004 to 2014. F

SUBMITTER: Lin TY 

PROVIDER: S-EPMC9918445 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature