Time-varying SUVr reflects the dynamics of dopamine increases during methylphenidate challenges in humans.

ABSTRACT: Dopamine facilitates cognition and is implicated in reward processing. Methylphenidate, a dopamine transporter blocker widely used to treat attention-deficit/hyperactivity disorder, can have rewarding and addictive effects if injected. Since methylphenidate's brain uptake is much faster after intravenous than oral intake, we hypothesize that the speed of dopamine increases in the striatum in addition to its amplitude underly drug reward. To test this we use simulations and PET data of [¹¹C]raclopride's binding displacement with oral and intravenous methylphenidate challenges in 20 healthy controls. Simulations suggest that the time-varying difference in standardized uptake value ratios for [¹¹C]raclopride between placebo and methylphenidate conditions is a proxy for t

SUBMITTER: Tomasi D 

PROVIDER: S-EPMC9918528 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature