Nanotopography reveals metabolites that maintain the immunomodulatory phenotype of mesenchymal stromal cells.

ABSTRACT: Mesenchymal stromal cells (MSCs) are multipotent progenitor cells that are of considerable clinical potential in transplantation and anti-inflammatory therapies due to their capacity for tissue repair and immunomodulation. However, MSCs rapidly differentiate once in culture, making their large-scale expansion for use in immunomodulatory therapies challenging. Although the differentiation mechanisms of MSCs have been extensively investigated using materials, little is known about how materials can influence paracrine activities of MSCs. Here, we show that nanotopography can control the immunomodulatory capacity of MSCs through decreased intracellular tension and increasing oxidative glycolysis. We use nanotopography to identify bioactive metabolites that modulate intracellular tension, grow

SUBMITTER: Ross EA 

PROVIDER: S-EPMC9918539 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature