Molecular insights into the structural and dynamical changes of calcium channel TRPV6 induced by its interaction with phosphatidylinositol 4,5-bisphosphate.

ABSTRACT: Transient receptor potential vanilloid subfamily member 6 (TRPV6) is an epithelial calcium channel that regulates the initial step of the transcellular calcium transport pathway. TRPV6 is expressed in the kidney, intestine, placenta, and other tissues, and the dysregulation of the channel is implicated in several human cancers. It has been reported that phosphatidylinositol 4,5-bisphosphate (PIP₂) activates TRPV6 and its close homologue TRPV5; however, the underlying molecular mechanism is less clear. Recently, a structure of rabbit TRPV5 in complex with dioctanoyl (diC₈) PIP₂, a soluble form of PIP₂, was determined by cryo-electron microscopy. Based on this structure, the structural model of human TRPV6 with PIP₂ was set up, and then

SUBMITTER: Wang L 

PROVIDER: S-EPMC9918602 | biostudies-literature | 2023 Aug-Sep

REPOSITORIES: biostudies-literature