A simple model for viral decay dynamics and the distribution of infected cell life spans in SHIV-infected infant rhesus macaques.

ABSTRACT: The dynamics of HIV viral load following the initiation of antiretroviral therapy is not well-described by simple, single-phase exponential decay. Several mathematical models have been proposed to describe its more complex behavior, the most popular of which is two-phase exponential decay. The underlying assumption in two-phase exponential decay is that there are two classes of infected cells with different lifespans. However, with the exception of CD4⁺ T cells, there is not a consensus on all of the cell types that can become productively infected, and the fit of the two-phase exponential decay to observed data from SHIV.C.CH505 infected infant rhesus macaques was relatively poor. Therefore, we propose a new model for viral decay, inspired by the Gompertz model where the decay

SUBMITTER: Sass J 

PROVIDER: S-EPMC9918703 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature