Proteomics identifies novel biomarkers of synovial joint disease in a canine model of mucopolysaccharidosis I.

ABSTRACT: Mucopolysaccharidosis I is a lysosomal storage disorder characterized by deficient alpha-L-iduronidase activity, leading to abnormal accumulation of glycosaminoglycans in cells and tissues. Synovial joint disease is prevalent and significantly reduces patient quality of life. There is a critical need for improved understanding of joint disease pathophysiology in MPS I, including specific biomarkers to predict and monitor joint disease progression, and response to treatment. The objective of this study was to leverage the naturally-occurring MPS I canine model and undertake an unbiased proteomic screen to identify systemic biomarkers predictive of local joint disease in MPS I. Synovial fluid and serum samples were collected from MPS I and healthy dogs at 12 months-of-age, and protein abunda

SUBMITTER: Zhang C 

PROVIDER: S-EPMC9918716 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature