An immune score reflecting pro- and anti-tumoural balance of tumour microenvironment has major prognostic impact and predicts immunotherapy response in solid cancers.

ABSTRACT:

Background

Cancer immunity is based on the interaction of a multitude of cells in the spatial context of the tumour tissue. Clinically relevant immune signatures are therefore anticipated to fundamentally improve the accuracy in predicting disease progression.

Methods

Through a multiplex in situ analysis we evaluated 15 immune cell classes in 1481 tumour samples. Single-cell and bulk RNAseq data sets were used for functional analysis and validation of prognostic and predictive associations.

Findings

By combining the prognostic information of anti-tumoural CD8⁺ lymphocytes and tumour supportive CD68⁺CD163⁺ macrophages in colorectal cancer we generated a signature of immune activation (SIA). The prognostic impact of SIA was independent o

SUBMITTER: Mezheyeuski A 

PROVIDER: S-EPMC9918750 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature