Correlation between speed and turning naturally arises for sparsely sampled cell movements.

ABSTRACT: Mechanisms regulating cell movement are not fully understood. One feature of cell movement that determines how far cells displace from an initial position is persistence, the ability to perform movements in a direction similar to the previous movement direction. Persistence is thus determined by turning angles (TA) between two sequential displacements and can be characterized by an average TA or persistence time. Recent studies documenting T cell movement in zebrafish found that a cell's average speed and average TA are negatively correlated, suggesting a fundamental cell-intrinsic program whereby cells with a lower TA (and larger persistence time) are intrinsically faster (or faster cells turn less). In this paper we confirm the existence of the correlation between turning and speed for s

SUBMITTER: Ganusov VV 

PROVIDER: S-EPMC9918869 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature