Naphthalimide-Piperazine Derivatives as Multifunctional "On" and "Off" Fluorescent Switches for pH, Hg²⁺ and Cu²⁺ Ions.

ABSTRACT: Novel 1,8-naphthalimide-based fluorescent probes NI-1 and NI-2 were designed and screened for use as chemosensors for detection of heavy metal ions. Two moieties, methylpyridine (NI-1) and hydroxyphenyl (NI-2), were attached via piperazine at the C-4 position of the napthalimide core resulting in a notable effect on their spectroscopic properties. NI-1 and NI-2 are pH sensitive and show an increase in fluorescence intensity at around 525 nm (switch "on") in the acidic environment, with pK_a values at 4.98 and 2.91, respectively. Amongst heavy metal ions only Cu²⁺ and Hg²⁺ had a significant effect on the spectroscopic properties. The fluorescence of NI-1 is quenched in the presence of either Cu²⁺

SUBMITTER: Prsir K 

PROVIDER: S-EPMC9918953 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature