Comprehensive Investigation on Associations between Dietary Intake and Blood Levels of Fatty Acids and Colorectal Cancer Risk.

ABSTRACT:

Background

Increasingly, studies have discovered that different fatty acids (Fas) are linked to colorectal cancer (CRC) risk.

Methods

We systematically searched Embase and Medline databases to identify eligible studies that examined the associations of different types of Fas with CRC risk. The effect estimates and their 95% confidence intervals (Cis) were pooled using a random-effects model. Subgroup and sensitivity analyses were performed to examine the robustness of the study findings.

Results

This study evaluated the associations of 28 dietary and 18 blood Fas with CRC risk by summarizing the most updated evidence from 54 observational and four Mendelian Randomization (MR) studies. The present findings suggested that high dietary intake of eicosapentaenoic acid (EP

SUBMITTER: Lu Y 

PROVIDER: S-EPMC9919095 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature