Rational Design of Nitrogen-Doped Carbon Dots for Inhibiting β-Amyloid Aggregation.

ABSTRACT: The fibrillization and abnormal aggregation of β-amyloid (Aβ) peptides are commonly recognized risk factors for Alzheimer's disease (AD) brain, and require an effective strategy to inhibit the Aβ deposition and treat AD. Herein, we designed and synthesized nitrogen-doped carbon dots (N-CDs) as an Aβ-targeted probe, which exhibits the capacity of inhibiting the 1-42 Aβ (Aβ_1-42) self-assembly in vitro. The N-CDs exhibited orange emission with an emission wavelength of 570 nm, which demonstrates their excellent optical properties with excitation-independent behavior. Meanwhile, the N-CDs have spherical morphologies with an average size of 2.2 nm, whose surface enriches the amino, carboxyl, and hydroxyl groups. These preparties are conducive

SUBMITTER: Liu H 

PROVIDER: S-EPMC9919344 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature