Instrumental variable estimation of the marginal structural Cox model for time-varying treatments.

ABSTRACT: Robins (1998) introduced marginal structural models, a general class of counterfactual models for the joint effects of time-varying treatments in complex longitudinal studies subject to time-varying confounding. Robins (1998) established the identification of marginal structural model parameters under a sequential randomization assumption, which rules out unmeasured confounding of treatment assignment over time. The marginal structural Cox model is one of the most popular marginal structural models for evaluating the causal effect of time-varying treatments on a censored failure time outcome. In this paper, we establish sufficient conditions for identification of marginal structural Cox model parameters with the aid of a time-varying instrumental variable, in the case where sequential rand

SUBMITTER: Cui Y 

PROVIDER: S-EPMC9919489 | biostudies-literature | 2023 Mar

REPOSITORIES: biostudies-literature