Genetic Variability of Complement Factor H Has Ethnicity-Specific Associations With Choroidal Thickness.

ABSTRACT:

Purpose

To identify genetic alleles associated with differences in choroidal thickness (CT) in a population-based multiethnic Asian cohort.

Methods

A population-based multiethnic Asian cohort without retinal pathology was subjected to spectral-domain OCT (SD-OCT) and genotyping of risk alleles in CFH, VIPR2, ARMS2, and CETP. Subfoveal choroidal thickness (SFCT) values were assessed from SD-OCT, and associations with the risk alleles were determined for each cohort.

Results

A total of 1045 healthy Asian individuals (550 Chinese, 147 Indians, 348 Malays) were prospectively enrolled in the study. Several CFH alleles (rs800292, rs1061170, and rs1329428) were associated with increased SFCT in Indians (+18.7 to +31.7 µm; P = 0.001-0.038) and marginally associated with decre

SUBMITTER: Fenner BJ 

PROVIDER: S-EPMC9919691 | biostudies-literature | 2023 Feb

REPOSITORIES: biostudies-literature